The Lone Star Conference returned to the South Region after temporarily joining the West in 2021.
Note: Teams that are italicized previously played in the NPSL and are returning from hiatus.
Due to the distance between teams, the Pacific Conference was split into two divisions.
The top two teams from each group qualified for the playoffs and play one-another in the conference semifinals.
Note: Games are hosted by the highest seed unless noted otherwise[23] Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner * = after extra time, ( ) = penalty shootout score Bold = winner* = after extra time, ( ) = penalty shootout score Paul Patterson, Justen Lopez Championship MVP: Coby Handy Jean Rodriguez (MOT)