The club played in the USL Championship, the second division of the United States soccer league system, and participated in the U.S. Open Cup.

Win Draw Loss Postponed Kickoff times are in CDT (UTC-05) unless shown otherwise On August 27, 2022, San Antonio clinched a spot in the 2022 USL Championship Playoffs.

On October 1, San Antonio secured the best record in the USL Championship regular season, guaranteeing home-field advantage throughout the playoffs.

Source: San Antonio FC The list is sorted by shirt number when total goals are equal.

Source: San Antonio FC The list is sorted by shirt number when total clean sheets are equal.