The playoffs began October 22, and concluded with the USL Championship Final on November 13.

[2] Defending title holders Orange County SC did not qualify for the playoffs.

[4] All playoff matches will be streamed live on ESPN+ except the Championship final on ESPN2, ESPN Deportes, and Sirius XM FC.

Similar to the 2022 MLS playoffs, the final featured the top seeds in the Eastern and Western Conferences, Louisville City FC and San Antonio FC, who were their conferences' regular-season and play-off champions.

For Louisville City, 2022 marks the fourth Championship final in five seasons, having won two of their previous three in 2017 and 2018.