4-Bromoanisole is the organobromine compound with the formula CH3OC6H4Br.

It is colorless liquid with a pleasant smell similar to that of anise seed.

4-Bromoanisole forms a Grignard reagent,[1] which reacts with phosphorus trichloride to give tris(4-methoxyphenyl)phosphine: 4-Bromoanisole forms the organozinc derivative CH3OC6H4ZnBr.

[2] 4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination.

[3] It interacts with genomic DNA (gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.