2JIH, 2V4B, 3Q2G, 3Q2H951011504ENSG00000154734ENSMUSG00000022893Q9UHI8P97857NM_006988NM_009621NP_008919NP_033751A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

[5][6] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.

The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity.

The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia.

This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.