9508330119ENSG00000156140ENSMUSG00000043635O15072n/aNM_014243NM_001081401NM_177872NP_055058n/aA disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.

[6] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

[6] Because of the high similarity to ADAMTS2, the major substrate of ADAMTS3 had been erroneously assumed to be procollagen II.

ADAMTS3 has been shown to cleave reelin, a protein that regulates the proper lamination of the brain cortex and whose signal activity is found to be disrupted in a number of neuropsychiatric conditions.

[9] A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.