81794224697ENSG00000142303ENSMUSG00000024299Q9H324P58459NM_001282352NM_030957NM_001329153NM_001329154NM_001329202NM_001329203NP_001269281NP_112219NP_001316083NP_001316131NP_001316132NP_766207A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.

[5] This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases.

ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat.

They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.

The product of this gene plays a major role in growth and in skin, lens, and heart development.