Located between Bay Street to the north and Congress Street to the south, it runs for about 1.10 miles (1.77 km) from a cul-de-sac in the west to East Broad Street in the east.

Bryan Street is named for the Bryan family (brothers Hugh, Jonathan and Joseph), of South Carolina, who assisted James Edward Oglethorpe in establishing the Savannah colony.

[2] Bryan Street passes through six squares on their northern side.

From west to east: Below is a selection of notable buildings and structures on Bryan Street, all in Savannah's Historic District.

From west to east:[3] In 1849, the Georgia Historical Society moved into a new construction, a Gothic Revival building on East Bryan Street.