Originally known only as Charlton Street singular, its addresses are now split between "West Charlton Street" and "East Charlton Street", the transition occurring at Bull Street in the center of the downtown area.

The street is named for Thomas Charlton, fifteenth mayor of Savannah.

[1] The street is entirely within Savannah Historic District, a National Historic Landmark District.

[2] Charlton Street passes through four squares on their southern side.

From west to east: Below is a selection of notable buildings and structures on Charlton Street, all in Savannah's Historic District.