Located between Habersham Street to the west and East Broad Street to the east, it runs for about 2.04 miles (3.28 km) from East Bay Street in the north to East Victory Drive (U.S. Route 80) in the south.

The street's directional flow is one-way (southbound), with a single lane for motor vehicles and a dedicated lane for cyclists.

[1] Its northern section passes through the Savannah Historic District, a National Historic Landmark District.

[2] Price Street runs beside seven squares.

From north to south: Below is a selection of notable buildings and structures on Price Street, all in Savannah's Historic District.