Located between Perry Street to the north and Harris Street to the south, it runs for about 0.90 miles (1.45 km) from Martin Luther King Jr. Boulevard in the west to Randolph Street in the east.

Originally known only as Liberty Street singular, its addresses are now split between "West Liberty Street" and "East Liberty Street", the transition occurring at Bull Street in the center of the downtown area.

The street is entirely within Savannah Historic District, a National Historic Landmark District.

[1] Liberty Street runs between seven squares.

From west to east: Below is a selection of notable buildings and structures on Liberty Street, all in Savannah's Historic District.