Its course was interrupted by around 0.14 miles (0.23 km) (between West Oglethorpe Avenue and West Liberty Street) by the construction of the Savannah Civic Center in 1974.

The street is named for Thomas Jefferson, third president of the United States.

[1] Its northern section passes through the Savannah Historic District, a National Historic Landmark District.

From north to south: Below is a selection of notable buildings and structures on Jefferson Street, all in Savannah's Historic District.

From north to south:[3] Club 1, at 1 Jefferson Street, is a gay nightclub where The Lady Chablis worked.