Clouston's hidrotic ectodermal dysplasia is a medical condition caused by mutations in a connexin gene, GJB6 or connexin-30, characterized by scalp hair that is wiry, brittle, and pale.
[1]: 507, 511, 517–16 Hidrotic ectodermal dysplasia 2, or Clouston syndrome (HED2) is characterized by partial or total alopecia, dystrophy of the nails, hyperpigmentation of the skin (especially over the joints), and clubbing of the fingers.
Sparse scalp hair and dysplastic nails are seen early in life.
In infancy, scalp hair is wiry, brittle, patchy, and pale.
Progressive hair loss may lead to total alopecia by puberty.