Crotonyl-coenzyme A is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan.

[3] A report by Alber and coworkers concluded that a specific CCR homolog was able to reduce crotonyl-coA to (2S)-ethyl malonyl-coA which was a favorable reaction.

[3] The specific CCR homolog came from the bacterium Rhodobacter sphaeroides.

[3] Post-translational modification of histones either by acetylation or crotonylation is important for the active transcription of genes.

[4] Histone crotonylation is regulated by the concentration of crotonyl-coA which can change based on environmental cell conditions or genetic factors.