[6][7][8][9] However, it is not licensed as monotherapy for stroke prophylaxis, although a Cochrane review suggested that dipyridamole may reduce the risk of further vascular events in patients presenting after cerebral ischemia.

[10] A triple therapy of aspirin, clopidogrel, and dipyridamole has been investigated, but this combination led to an increase in adverse bleeding events.

[12] According to Association of Anaesthetists of Great Britain and Ireland 2016 guidelines, dipyridamole is considered to not cause risk of bleeding when receiving neuroaxial anaesthesia and deep nerve blocks.

It does not therefore require cessation prior to anaesthesia with these techniques, and can continue to be taken with nerve block catheters in place.

[13] Dipyridamole overdose can be treated with aminophylline[2]: 6  or caffeine which reverses its dilating effect on the blood vessels.