1JO61024272413ENSG00000197584ENSMUSG00000037610Q9Y691Q9CZM9NM_001278911NM_005832NM_181361NM_028231NP_001265840NP_005823NP_852006NP_082507Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.

[5][6] Big Potassium (BK) channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability.

The protein encoded by the KCNMB2 gene is an auxiliary beta subunit which influences the calcium sensitivity of BK currents and, following activation of BK current, causes persistent inactivation.

The KCNMB2 gene is homologous to three other genes found in mammalian genomes: KCNMB1 (found primarily in smooth muscle), KCNMB3, and KCNMB4 (the primary brain BK auxiliary subunit).

This article incorporates text from the United States National Library of Medicine, which is in the public domain.