The district headquarters are approximately 65 kilometres (40 mi), by road, northeast of Mbarara, the largest town in the Ankole sub-region.

The sub-region was home to an estimated population of 10,577,900 million as of 2020, according to the national census conducted that year.

[3][4] The country home of the current Uganda President Yoweri Museveni is in Rwakitura, Nyabushozi County, in Kiruhura District.

[7] The produce is sold locally and also marketed to Kampala, Uganda's capital and largest city about 240 kilometres (150 mi) to the east of the district.

[8] Amos Dairies Uganda Limited, a subsidiary of Amos Dairies Limited, is setting up a milk-processing plant at Akageti in Kiruhura District, with the capacity to process more than 2 million litres of milk annually.