The district headquarters at Rubirizi are located approximately 97 kilometres (60 mi) northwest of Mbarara, the largest city in Ankole sub-region.

[2] This is approximately 364 kilometres (226 mi), southwest of Kampala, Uganda's capital and largest city.

[5] It is one of the districts that constitute Ankole sub-region, home to an estimated 3.9 million Banyankole, in 2018, according to CIA Factbook.

The key tourist areas of the park in the district include: In 1991, the national population census estimated the district population at about 75,400.

The annual rate of population growth in the district was calculated to average 1.9 percent, between 2014 and 2020.