The town of Kisoro is the site of the district headquarters.

Kisoro Municipality includes Metropolitan International University, a secular, private educational institution.

Kisoro District is bordered by Kanungu District to the north, Kabale District to the east, Rwanda to the south, and the Democratic Republic of the Congo to the west.

The town of Kisoro is approximately 45 kilometres (28 mi), by road, west of Kabale, the largest town in the sub-region.

The population was estimated at 220,300 during the 2002 national census.