The district headquarters are in the Kibbuuku town council.

The Ntoroko District is bordered by the Democratic Republic of the Congo to the west and north, separated by the winding Semuliki River, has a maritime boundary with two Bunyoro districts; Kikuube District to the north-north-east and Kagadi District to the north-east.

The town of Ntoroko (officially Kanara Town Council is approximately 84 km north-west of Fort Portal City, the regional capital by road, 111 from Bundibugyo and approximately 162 km by road, north-east of Kasese, the other larger towns in the Rwenzori sub-region[1] This location is approximately 376 kilometres (234 mi), by road, west of Kampala, the capital and largest city of Uganda.

[2] The Ntoroko District was created by the Ugandan Parliament and became operational on 1 July 2010.

In 2014, the national census and household survey enumerated the district population at 67,005.