The regiment is based in Venice and assigned to the Cavalry Brigade "Pozzuolo del Friuli".

[8] In 1550, the Republic of Venice formed a corps of embarked troops for the Venetian fleet, which were named Fanti da Mar (Infantry of the Sea).

Present on all Venetian ships the Fanti da Mar were disbanded after the Fall of the Republic of Venice on 12 May 1797.

On 21 October 1848, the unit moved through the Venetian Lagoon to attack Austrian forces on the Cavallino peninsula.

On 4 May 1849, Austrian forces, which in the meantime had defeated the Kingdom of Sardinia in the First Italian War of Independence, began the Siege of Venice with an attack against the fort of Marghera.

On 26 May 1849, the fort at Marghera had to be evacuated and Venice's defenders fell back to the city itself, which was heavily bombarded by the Austrian Army and Navy.

[10][11] In May 1915, just before Italy's entry into World War I, the 4th Engineer Regiment (Pontieri) formed the 15th Lagunari Company.

[10][11] On 28 August 1918, the Royal Italian Army formed the 8th Engineer Regiment (Lagunari) in Ferrara, which received the eight existing Laguanri companies.

On 1 March 1956, the command of the Lagoonal Forces Sector was assigned to a colonel of the Italian Army and the process of detaching the navy component began.

The regiment was assigned the traditions of the Venetian Fanti da Mar and the Royal Italian Army's Lagunari.

[6][8][10] After its formation the Amphibious Troops Command was assigned to the Mechanized Division "Folgore".

On 12 November 1976, the President of the Italian Republic Giovanni Leone assigned with decree 846 the flag and traditions of the Lagunari Regiment "Serenissima" and the traditions of the Fanti di Mar to the 1st Lagunari Battalion "Serenissima".

[6][8][10][15] On 25 June 1984, the Lagunari became a speciality within the Italian Army's infantry arm and, on 26 August 1984, the Italian Armed Forces' Military Vicar Gaetano Bonicelli assigned Saint Mark the Evangelist as patron saint of the new speciality.

[6][8][10] On 31 October 1986, the Mechanized Division "Folgore" was disbanded and the next day the Amphibious Troops Command was assigned to the 5th Army Corps.

The reformed regiment also incorporated the Nautical Vehicles Company of the disbanded Amphibious Battalion "Sile".

On 16 September 1996, the regiment was transferred from the 5th Army Corps to the Support Units Command "Legnano".

On 1 December 2000, the Lagunari Regiment "Serenissima" joined the Cavalry Brigade "Pozzuolo del Friuli".

[6][8] The regiment repeatedly deployed to Bosnia and Herzegovina and Kosovo as part of NATO's peacekeeping missions.

On 5 and 6 August 2004, forces of Muqtada al-Sadr's Mahdi Army fought units of the Cavalry Brigade "Pozzuolo del Friuli" for control of the three main bridges over the Euphrates river in Nasiriyah.

In 2010-11, the regiment deployed to Farah in Afghanistan as part of NATO's International Security Assistance Force.

[6] In 2019, the regiment deployed to Herat in Afghanistan as part of NATO's Resolute Support Mission.

The fusilier platoons' maneuver support squads include the platoon's commander and deputy commander, two drivers, a radio operator, and a fire support squad, which is equipped with a Minimi machine gun, a Panzerfaust 3 anti-tank rocket launcher, and a M6C-210 60mm mortar.