Mexico competed at the 1980 Summer Olympics in Moscow, USSR.

45 competitors, 36 men and 9 women, took part in 43 events in 12 sports.

[1] Men's 10,000 metres Men's Marathon Men's 20 km Walk Men's 50 km Walk Men's Light Flyweight (– 48 kg) Men's Flyweight (– 51 kg) Men's Bantamweight (– 54 kg) Men's Featherweight (– 57 kg) Men's Springboard Men's Platform Two male pentathletes represented Mexico in 1980.

Women's 100 m Breaststroke Women's 4 × 100 m Freestyle Relay Women's 4 × 100 m Medley Relay Men's freestyle 48 kg Men's Greco-Roman 48 kg