It is one of the key nodes of the Milan suburban railway service as the southern gate of the Milanese urban network.

Its function was to serve as the cargo station for the then-autonomous town of Rogoredo, today included in the city administration as part of Milan's southeastern border with San Donato Milanese.

This step came when the city of Milan started to grow faster and various factories were established in the area, such as the Montedison chemical facility and the Redaelli steel plant.

In 1999, work restarted to add four tracks to allow integration with the Passante railway and the high-speed line, as well as to complete the platform roofing.

The importance of this station has increased with the extension of the Milan suburban railway service to Pavia and Lodi, and the new residential district called Santa Giulia.