[6] Molten niobium pentoxide has lower mean coordination numbers than the crystalline forms, with a structure comprising mostly NbO5 and NbO6 polyhedra.

Pure Nb2O5 can also be prepared by hydrolysis of NbCl5:[8] A method of production via sol-gel techniques has been reported hydrolysing niobium alkoxides in the presence of acetic acid, followed by calcination of the gels to produce the orthorhombic form,[3] T-Nb2O5.

[11] Nano-sized niobium pentoxide particles have been synthesized by LiH reduction of NbCl5, followed by aerial oxidation as part of a synthesis of nano structured niobates.

Treating Nb2O5 with aqueous NaOH at 200 °C can give crystalline sodium niobate, NaNbO3 whereas the reaction with KOH may yield soluble Lindqvist-type hexaniobates, Nb6O8−19.

Nb2O5 have been considered for use as an anode in a lithium-ion battery, given that their ordered crystalline structure allows charging speeds of 225 mAh g−1 at 200 mA g−1 across 400 cycles, at a Coulombic efficiency of 99.93%.