[5] Sodium bifluoride is produced by neutralizing waste hydrogen fluoride, which results from the production of superphosphate fertilizers.

The process occurs in two steps, illustrated with the hydroxide:[4] Sodium bifluoride reacts with water or moist skin to produce hydrofluoric acid.

[4] The compound also has applications in cleaning, capitalizing on the affinity of fluoride for iron and silicon oxides.

[8] Sodium bifluoride's biological applications include the preservation of zoological and anatomical samples.

Sodium bifluoride also aids in the precipitation of calcium ions during the process of nickel electroplating.

[10] Sodium bifluoride is corrosive and an irritant upon contact with skin and can cause blistering and inflammation.

Ingestion of sodium bifluoride dust can cause burning, coughing, and sneezing, as a result of irritating the gastrointestinal and respiratory tracts.

[3] Exposure to sodium bifluoride repeatedly or over a long time can result in fluorosis.