This method can be used for several applications such as isolating and engineering antibodies[1] and determining host-microbe interactions.
[2] The yeast display technique was first published by the laboratory of Professor K. Dane Wittrup and Eric T.
The use of magnetic separation and flow cytometry in conjunction with a yeast display library can be highly effective method to isolate high affinity protein ligands against nearly any receptor through directed evolution.
[citation needed] Advantages of yeast display over other in vitro evolution methods include eukaryotic expression and post translational processing, quality control mechanisms of the eukaryotic secretory pathway, minimal avidity effects, and quantitative library screening through fluorescent-activated cell sorting (FACS)[citation needed].
Yeast are eukaryotic organisms that allow for complex post-translational modifications to proteins that no other display libraries are able to provide[citation needed].