The 2010 Fergana Challenger was a professional tennis tournament played on outdoor hard courts.

It was part of the 2010 ATP Challenger Tour.

[1] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received special exempt into the main draw: The following player received entry with a protected ranking: Evgeny Kirillov def.

Zhang Ze, 6–3, 2–6, 6–2 Brendan Evans / Toshihide Matsui def.

Gong Maoxin / Li Zhe, 3–6, 6–3, [10–8]