In addition to the domestic league, Ajax participated in this season's edition of the KNVB Cup, the UEFA Champions League and the Johan Cruyff Shield.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Eredivisie The league fixtures were announced on 11 June 2021.

[31] The draw for the group stage was held on 26 August 2021.