The 2021–22 CAF Champions League group stage were played from 11 February to 3 April 2022.
The draw for the group stage was held on 28 December 2021, 11:30 GMT (13:30 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.
The teams were seeded by their performances in the CAF competitions for the previous five seasons (CAF 5-year ranking points shown next to every team).
The winners and runners-up of each group advanced to the quarter-finals of the knockout stage.
If tied on points, tiebreakers were applied in the following order (Regulations III.