The team that scored more goals on aggregate over the two legs advanced to the next round.
If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out.
In the final, which was played as a single match, if the score was level at the end of normal time, extra time was played and if the score was still level, the winners were decided by a penalty shoot-out.
The bracket of the knockout stage was determined as follows: The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 5 April 2022, 13:00 GMT (15:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.
The final was played on 20 May 2022 at Godswill Akpabio International Stadium, Uyo.