The 2021–22 CAF Confederation Cup qualifying rounds were played from 10 September to 6 February 2022.
[1] A total of 51 teams competed in the qualifying rounds to decide the 16 places in the group stage of the 2021–22 CAF Confederation Cup.
The draw for the qualifying rounds was held on 13 August 2021 at the CAF headquarters in Cairo, Egypt.
[2][3][4] The entry round of the 51 teams entered into the draw was determined by their performances in the CAF competitions for the previous five seasons (CAF 5-year ranking points shown in parentheses).
[5] In the qualifying rounds, each tie was played on a home-and-away two-legged basis.
If the aggregate score was tied after the second leg, the away goals rule was applied, and if still tied, extra time won't be played, and the penalty shoot-out was used to determine the winner (Regulations III.
Gor Mahia won on walkover after Al-Ahli Merowe withdrew from the second leg in Kenya.
Al Ahli Tripoli won on walkover after Biashara United failed to appear for the second leg in Libya.
[10] Interclube won on walkover after CFFA withdrew from the second leg in Angola.
The draw for the play-off round was held on 26 October 2021, 11:00 GMT (13:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.
Al Ahli Tripoli won 4–2 on penalties.
Al Ittihad won on walkover after Enyimba failed to travel to Libya for the first leg.
Orlando Pirates won on walkover after LPRC Oilers withdrew from the second leg in South Africa.