The 2021–22 CAF Champions League qualifying rounds were played from 10 September to 24 October 2021.
[1] A total of 54 teams competed in the qualifying rounds to decide the 16 places in the group stage of the 2021–22 CAF Champions League.
The draw for the qualifying rounds was held on 13 August 2021 at the CAF headquarters in Cairo, Egypt.
[3][4][5] The entry round of the 54 teams entered into the draw was determined by their performances in the CAF competitions for the previous five seasons (CAF 5-year ranking points shown in parentheses).
In the qualifying rounds, each tie was played on a home-and-away two-legged basis.
If the aggregate score is tied after the second leg, the away goals rule was applied, and if still tied, extra time won't be played, and the penalty shoot-out was used to determine the winner (Regulations III.
The bracket of the draw was announced by the CAF on 13 August 2021.
Notes: LPRC Oilers won 3–2 on aggregate.
Petro de Luanda won on away goals.
Espérance de Tunis won 1–0 on aggregate.
Étoile du Sahel won 5–1 on aggregate.
Petro de Luanda won 4–2 on aggregate.