In addition to the domestic league, Lokomotiv Moscow participated in this season's editions of the Russian Cup, the Russian Super Cup and the UEFA Europa League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: FBref The draw for the group stage was held on 27 August 2021.