[1] Kadetten Schaffhausen won their twelfth title.
[2] The following 14 clubs competed in the Slovenian First League during the 2021–22 season: All three rounds of the playoffs were played in a best-of-five format, with the higher seeded team playing the first, third and fifth (if it was necessary) game at home.
Kadetten Schaffhausen won the Finals, 3–0 on series.
[2] The playout were played in a best-of-five format, with the higher seeded team playing the first, third and fifth (if it was necessary) game at home.
RTV 1879 Basel won 3–0 on series and retained their Swiss Handball League spot, Chênois Genève was relegated to the Nationalliga B.