The 2021–22 Women's EHF Champions League group stage began on 11 September 2021 and concluded on 20 February 2022 to determine the ten teams who advanced to the knockout stage of the 2021–22 Women's EHF Champions League.
[1][2] The composition of the seeding pots for the group stage draw was announced on 30 June 2021.
[3] In each group, teams played against each other in a double round-robin format, with home and away matches.
If no ranking can be determined, a decision shall be obtained by EHF through drawing of lots.
Due to the COVID-19 pandemic, each local health department allows a different number of spectators.