On 25 August 2021 Newport County faced Southampton of the Premier League in the second round of the 2021–22 EFL Cup but they lost heavily 8–0.

[7] On the same day, Cardiff City coach Carl Serrant was appointed assistant manager to Rowberry at Newport County.

Source: [citation needed] Newport County's fixtures were released on 24 June 2021.

[11] On 7 July, the fixture dates against Mansfield Town were reversed due to pitch renovation work at Newport's Rodney Parade ground during August 2021.

The draw for the Welsh League Cup sponsored by Nathaniel MG was made on 24 June 2021 with Newport County and Denbigh Town invited as wildcard entries.