The 2021–22 South African Premiership (known as the DSTV Premiership for sponsorship reasons) was the 26th season of the Premier Soccer League since its establishment in 1996.
Mamelodi Sundowns won the title for the fifth consecutive year, qualifying for the 2022–23 CAF Champions League along with Cape Town City.
Royal AM and Nedbank Cup runners-up Marumo Gallants qualified for the 2022–23 CAF Confederation Cup.
The following teams changed division since the 2020–21 season.
Relegated from 2020–21 South African Premier Division Promoted to 2021–22 South African Premiership