The 2021 Berkeley Tennis Club Challenge was a professional women's tennis tournament played on outdoor hard courts.

It was the third edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Berkeley, California, United States between 27 September and 3 October 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry as a special exempt: The following players received entry from the qualifying draw: