The 2021 LTP Charleston Pro Tennis II was a professional women's tennis tournament played on outdoor clay courts.

It was the sixth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Charleston, South Carolina, United States between 21 and 27 June 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry as a special exempt: The following players received entry from the qualifying draw: