The 2021 Open Araba en Femenino was a professional women's tennis tournament played on outdoor hard courts.

It was the second edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Vitoria-Gasteiz, Spain between 12 and 18 July 2021.

[1] The following players received wildcards into the singles main draw: The following players received entry using protected rankings: The following player received entry using a junior exempt: The following players received entry from the qualifying draw: The following players received entry as lucky losers: