The 2021 Engie Open Andrézieux-Bouthéon 42 was a professional women's tennis tournament played on indoor hard courts.

It was the eleventh edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Andrézieux-Bouthéon, France between 25 and 31 January 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a junior exempt: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: