The 2021 Henderson Tennis Open was a professional women's tennis tournament played on outdoor hard courts.

It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Henderson, Las Vegas, United States between 4 and 10 October 2021.

[1] The following players received wildcards into the singles main draw: The following players received entry using protected rankings: The following players received entry from the qualifying draw: