The 2021 ITS Cup was a professional women's tennis tournament played on outdoor clay courts.

It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Olomouc, Czech Republic between 19 and 25 July 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry using a junior exempt: The following players received entry from the qualifying draw: