The 2021 ITF World Tennis Tour Maspalomas was a professional women's tennis tournament played on outdoor clay courts.

It was the first edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in San Bartolomé de Tirajana, Spain between 16 and 22 August 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry as a special exempt: The following players received entry from the qualifying draw: