The 2021 Copa LP Chile was a professional women's tennis tournament played on outdoor clay courts.

It was the fourth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Santiago, Chile between 8 and 14 November 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following players received entry as lucky losers: