The 2021 Engie Open Saint-Gaudens Occitanie was a professional women's tennis tournament played on outdoor clay courts.

It was the twenty-fourth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour.

It took place in Saint-Gaudens, France between 10 and 16 May 2021.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry as a junior exempt: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: