Amudat, where the district headquarters are located, lies approximately 38 kilometres (24 mi), by road, northeast of Nakapiripirit, the nearest large town.

[1] This location is approximately 400 kilometres (250 mi), by road, northeast of Kampala, Uganda's capital and largest city.

According to the 2002 national census, Karamoja sub-region was home to close to one million people, at that time.

The 2002 national census estimated the population in the district at approximately 63,600.

The district population was determined to be growing at an annual rate of 6.1%, between 2002 and 2012.