[2] Nsiika, the location of the district headquarters, is approximately 53 kilometres (33 mi) northwest of Mbarara, the largest city in Ankole sub-region.

[3] This location is approximately 310 kilometres (190 mi), by road, southwest of Kampala, the capital of Uganda and the largest city in that country.

[5] Due to the marked scarp that follow its southern, eastern and much of the northern boundaries, Buhweju is considered to be the most isolated county in Ankole.

The district is part of Ankole sub-region, home to an estimated 2.56 million people, according to the 2014 national census.

[8] Buhweju District has proven reserves of gold,[9] lime, copper,[10] and timber.