Busia District borders Tororo District to the north, Busia County, Kenya to the east, Namayingo District to the south, and to the south-west, and Bugiri District to the west.

Busia, Uganda, the site of the district headquarters, is approximately 35 km (22 mi) by road south of Tororo, the nearest large town.

In 2002, the national census estimated the population at 225,000.

In 2012, the mid-year population was estimated at 297,600.

[2] Notable people from Busia District include: The following points of interest are in the district: