It rises near Hinton Blewitt, flows through Cameley, Temple Cloud, Camerton, Dunkerton and Combe Hay.

The Long Dole Wood and Meadows SSSI is situated on the flood plain of a valley formed by a tributary of the brook.

There are several springs dotted along the valley sides and the resultant streams are often lined with trees.

[3] The area is of interest to the Cam Valley Wildlife Group along with nearby Wellow Brook, The 1953 film The Titfield Thunderbolt,[4] an Ealing Studios comedy about a group of villagers attempting to run a service on a disused branch line, was filmed on the recently closed Camerton branch of the Bristol and North Somerset Railway branch line along the Cam Brook valley.

The Cam Valley Morris Men are based in nearby Priddy[6] and following the cider harvest, can often be seen in Kilmersdon for the traditional celebrations of wassailing.